Gwent Police is appealing for information to locate a missing patient.
23-year-old Richard Williams was being treated at St Cadocs hospital in Caerleon and went missing on Saturday afternoon.
Police are treating Mr Williams as a vulnerable adult.
He is not considered to be a risk to the public.
He is described as being approximately 5ft 6ins tall, of medium build with short brown hair.
He was last seen wearing a grey tracksuit top with stripes on the arms, grey tracksuit bottoms and white trainers.
It is believed that Mr Williams has connections in Newport, Gloucestershire and Nottingham.
Anyone with information about his whereabouts is asked to call Gwent Police on 01633 838111.
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